Detailed instructions which take about 2 minutes are linked at the model below.

https://www.printables.com/model/216209-adding-the-ender-3-s1-printer-profile-in-cura-5413

Note: Make sure to download the latest simple validation print from the link above repeated description below.

Cura does not have an Ender 3 S1 profile or for the Ender 3 S1 Pro. So people stick with the Creality slicer (older version of Cura rebranded) or they use Cura's Ender 3 Pro profile and then adjust the machine settings and import profiles or they try out Prusa slicer which has a E3S1 profile.

This works but wouldn't it be nice to select from the list of printers in Cura and be able to pick the Ender 3 S1 in the list?