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Subutex is the brand name for a medication that contains buprenorphine, a partial opioid agonist, and naloxone, an opioid antagonist. Buprenorphine attaches to the same receptors in the brain that opioids, like heroin and prescription painkillers, do but activates them to a lesser degree. This unique mechanism helps to reduce cravings and withdrawal symptoms without producing the same euphoric high associated with full opioids.