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Methadone operates through its action on the opioid receptors in the brain, particularly the mu-opioid receptors. Unlike other opioids, methadone has a long half-life, which allows it to stay active in the body for an extended period. This means it can alleviate withdrawal symptoms and cravings in individuals with opioid addiction without producing the "high" associated with illicit opioids like heroin. Methadone’s long duration of action also makes it less susceptible to the cycle of rapid addiction and withdrawal that many face with short-acting opioids.