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Vicodin is a prescription medication that combines two active ingredients: hydrocodone, an opioid pain reliever, and acetaminophen, a non-opioid pain reliever commonly known as Tylenol. Hydrocodone works by altering the way the brain and nervous system respond to pain, while acetaminophen enhances its pain-relieving effects and can also reduce fever. Vicodin is typically prescribed for the relief of moderate to severe pain, especially when other pain relief options are inadequate.