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It's often prescribed for conditions like post-operative pain, chronic pain, or pain associated with cancer. Tramadol is available in various forms, including immediate-release and extended-release tablets, as well as injections. Tramadol is a prescription medication used to treat moderate to severe pain. It belongs to a class of drugs known as opioid analgesics, which work by changing the way your brain and nervous system respond to pain. Unlike some other opioids, tramadol also affects the levels of serotonin and norepinephrine in your brain, which can enhance its pain-relieving effects.