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Typically, tramadol 100mg tablets are taken every 4 to 6 hours as needed for pain relief. However, it's essential to follow your doctor's instructions, as individual dosing may vary. It's also important to use this medication responsibly, as it can be habit-forming and may have side effects. Tramadol 100mg is a specific dosage of tramadol, a prescription medication used to treat moderate to moderately severe pain. It's often prescribed for conditions like post-operative pain, chronic pain, or pain associated with cancer. This medication works by changing how your brain and nervous system respond to pain, and it also affects the levels of serotonin and norepinephrine in your brain.