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Chronic Pain Management: Methadone is used for severe, ongoing pain in patients who need continuous pain relief over a long period. Opioid Addiction Treatment: Methadone is commonly used to help individuals reduce or quit the use of heroin or other opioids. It helps prevent withdrawal symptoms and cravings. How It Works: Methadone acts on the same opioid receptors in the brain as other opioids but with a slower onset and longer duration of action, reducing cravings and withdrawal effects without the intense high.