sirtuin biology in medicine by kenneth maiese pdf rnbc

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"Sirtuin Biology in Medicine" by Kenneth Maiese explores the role of sirtuins, a family of proteins involved in cellular regulation and longevity, in various medical contexts. Sirtuins are linked to critical processes like aging, metabolism, and stress response, making them a focal point for understanding age-related diseases such as Alzheimer's and cardiovascular disorders. Maiese delves into how sirtuins can influence gene expression, promote DNA repair, and enhance cellular resilience. The book discusses therapeutic potential, examining compounds like resveratrol that activate sirtuins, and their implications for developing interventions to combat age-associated decline. By investigating the mechanisms through which sirtuins operate, Maiese aims to provide insights into new strategies for enhancing healthspan and addressing chronic illnesses. Ultimately, the work underscores the importance of sirtuins in advancing medical science and improving patient outcomes.