privileged structures in drug discovery pdf lzwh

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==> privileged structures in drug discovery pdf <==

"Privileged structures" in drug discovery refer to molecular frameworks or scaffolds that exhibit a high propensity for binding to a variety of biological targets. These structures are often identified through extensive screening and can serve as starting points for the design of new drugs. The concept is based on the observation that certain chemical motifs consistently produce compounds with favorable biological activity across diverse targets, making them "privileged" in the context of medicinal chemistry. By delving into these structures, researchers can optimize their properties through modifications, ultimately leading to the development of effective therapeutics. This approach not only streamlines the drug discovery process but also increases the likelihood of success by focusing on versatile scaffolds that have already demonstrated a capacity for interaction with various biomolecules. Consequently, privileged structures can play a critical role in the search for new drugs, as they help to guide the selection of candidates with the ultimate goal of achieving potent and selective pharmacological profiles.