privileged structures in drug discovery medicinal chemistry and synthesis by larry yet pdf whgd
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"Privileged Structures in Drug Discovery: Medicinal Chemistry and Synthesis" by Larry Yet discusses the concept of privileged structures—molecular frameworks that exhibit a diverse range of biological activities across different targets. These structures serve as essential scaffolds in drug discovery, as they can be modified to enhance pharmacological properties while maintaining their core efficacy. The book outlines various classes of privileged structures, their synthetic routes, and the rationale behind their selection in medicinal chemistry. It emphasizes the importance of structure-activity relationship (SAR) studies in optimizing these compounds for specific therapeutic applications. By analyzing case studies and recent advancements, Yet provides insights into how these privileged structures facilitate the drug development process, enabling researchers to rapidly screen and synthesize compounds with desirable attributes. Furthermore, the text discusses the integration of computational methods in identifying and refining privileged structures, thus bridging traditional chemistry with modern computational techniques. Overall, the work serves as a comprehensive guide for medicinal chemists seeking to leverage privileged structures in their drug discovery endeavors, highlighting their pivotal role in designing effective and selective pharmaceuticals.