patient derived xenograft models of human cancer 2017 edition by peter w gout pdf xocu

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==> patient derived xenograft models of human cancer 2017 edition by peter w gout pdf <==

"Patient-Derived Xenograft Models of Human Cancer: 2017 Edition" by Peter W. Gout is a comprehensive guide focused on the use of patient-derived xenograft (PDX) models in cancer research. PDX models involve implanting human tumor tissues into immunocompromised mice, allowing for the study of human cancers in a living organism while preserving the biological characteristics of the original tumors. This book discusses the methodologies for developing and utilizing PDX models, including tumor collection, engraftment techniques, and the evaluation of tumor behavior in vivo. It highlights the importance of these models in preclinical drug testing, providing insights into tumor heterogeneity, treatment responses, and mechanisms of resistance. Additionally, the book addresses the potential of PDX models to aid in personalized medicine, as they can mimic patient-specific tumor biology more closely than traditional cell line models. By detailing the latest advancements and challenges in the field, Gout's work serves as a crucial resource for researchers and clinicians aiming to enhance cancer treatment strategies through the application of PDX technology.